文献_Biomarkers of Ovarian Reserve.pdfVIP

REVIEW Biomarkers of Ovarian Reserve William E. Roudebush, Wendy J. Kivens and Jessica M. Mattke Beckman Coulter, Inc., Immunoassay Business Group, Chaska, MN, U.S.A. Abstract: The primary function of the female ovary is the production of a mature and viable oocyte capable of fertilization and subsequent embryo development and implantation. At birth, the ovary contains a fi nite number of oocytes available for folliculogenesis. This fi nite number of available oocytes is termed “the ovarian reserve”. The determination of ovarian reserve is important in the assessment and treatment of infertility. As the ovary ages, the ovarian reserve will decline. Infer- tility affects approximately 15%–20% of reproductive aged couples. The most commonly used biomarker assay to assess ovarian reserve is the measurement of follicle stimulating hormone (FSH) on day 3 of the menstrual cycle. However, anti- müllerian hormone and inhibin-B are other biomarkers of ovarian reserve that are gaining in popularity since they provide direct determination of ovarian status, whereas day 3 FSH is an indirect measurement. This review examines the physical tools and the hormone biomarkers used to evaluate ovarian reserve. Keywords: ovarian reserve, FSH, inhibin-B, AMH/MIS Introduction The primary function of the female ovary is the production of a mature and viable oocyte capable of fertilization and subsequent embryo development and implantation. At birth, the ovary contains a fi nite number of oocytes available for folliculogenesis. This fi nite number of available oocytes is termed “the ovarian reserve”. The determination of ovarian reserve is important in the assessment and treatment of infertility. As the ovary ages, the ovarian reserve will decline. Ovarian reserve (OR) refers to the number and quality of oocytes that, at any given age, are available to