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correspondence with vitamin B12, but both continue to have symp- toms of peripheral neuropathy. No PEG 25% PEG, 1:1 dilution 1800 There have been reports of false normal re- sults for vitamin B levels generated by automat- 1600 12 1400 ed analyzers when the serum of patients with ) l m megaloblastic anemia is evaluated. The results / 1200 g p ( have been attributed to the possibility that high 2 1000 1 B levels of intrinsic factor–blocking antibodies inter- n 800 i fere with the assay.1,2 Today, vitamin B12 assays m 600 a t i are primarily performed on automated analyzers V 400 that apply a method based on the competitive 200 binding of serum vitamin B12 with reagent intrin- 0 sic factor. Many of these platforms have also
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