Toll样受体4对动脉粥样硬化发生、发展的研究进展.pdfVIP

第24卷第10期 生命科学 Vol. 24, No. 10 2012年10月 Chinese Bulletin of Life Sciences Oct., 2012 文章编号：1004-0374(2012) 10-1174-05 Toll 4 样受体 对动脉粥样硬化发生、发展的研究进展 郑晓云，刘先哲* (三峡大学人民医院心内科，宜昌443000) 摘　要 ：动脉粥样硬化(atherosclerosis, AS) 是多种细胞、炎性介质参与形成的慢性炎症性疾病。Toll 样受 体家族(Toll like receptors, TLRs) 中的TLR4 是机体重要的诱导分泌多种炎性因子的模式识别受体。现有证 据表明，TLR4 不仅产生多种炎性因子诱发血管炎症反应，而且促进AS 斑块形成和发展，造成斑块不稳定， 甚至破裂，对AS 的发生、发展具有重要作用。因此，了解TLR4 对AS 的影响有助于发现新的治疗靶点和 对策。主要对TLR4 在AS 发病机制和易损斑块发展中的作用进行综述。 关键词 ：Toll 样受体4 ；动脉粥样硬化；心血管疾病 中图分类号 ：R543.3 ；R592　　文献标志码 ：A Advance in Toll like receptor 4 affect the initiation and development of atherosclerosis ZHENG Xiao-Yun, LIU Xian-Zhe* (Department of Cardiology, the Peoples Hospital Affiliated to China Three Gorges University, Yichang 443000, China) Abstract: Atherosclerosis (AS) is a multi-factorial chronic inflammatory disease, which is caused by a variety of cells, inflammatory mediators. TLR4, the member of the family of Toll like receptors(TLRs), is an important receptor of pattern recognition receptors, could induce the secretion of many inflammatory cytokines. The available evidence suggests that TLR4 may play a pivotal role in initiation and progression of atherosclerosis, leading to vascular inflammation and plaque growth. Thus, understanding the correlation between TLR4 and AS could be beneficial to the discovery of new therapeutic targets and strategies. In this review, we discuss the effect of TLR4 in the pathogenesis of AS and vulnerable plaque development. Key words: Toll like receptor 4; atherosclerosis; cardiovascular disease 动脉粥样硬化(atherosclerosis, AS) 是一种慢性 配体结合后可诱导产生大量促炎因子和