梅毒螺旋体IgM抗体对于神经梅毒的诊断意义.pdfVIP

3·76 · 中国皮肤性病学杂志2002 年 11 月第 16 卷第 6 期　　Chin J Derm Venereol ,Nov 2002 ,Vol. 16 ,No. 6 梅毒螺旋体 IgM 抗体对于神经梅毒的诊断意义 施辛 ,杨辰 ,石怡珍 ,苏玉华 ,刘秀丽 ,吾为一 　　[摘 　要] 　目的 　探讨检测脑脊液中梅毒螺旋体 IgM 抗体对于神经梅毒的诊断意义。方法 　神经梅毒组 21 例 , 以 无神经系统被累的各期梅毒组 28 例、非梅毒组 28 例为对照。对三组患者腰穿取脑脊液 ,采用抗体捕获酶联免疫吸附分 析技术 ,进行梅毒螺旋体 IgM 抗体检测。结果 　神经梅毒组脑脊液 TpIgM 检测的阳性率为 71. 4 % ,两对照组则均为 0 , ( ) 差异有高度显著性 u = 5 . 37 , P 0. 01 。脑脊液 TpIgM 试验、VDRL/ RPR 试验在神经梅毒组的阳性率分别为 71. 4 % 、 ( 2 ) 33. 3 % , 差异有显著性 χ= 4. 90 , P 0. 05 。结论 　脑脊液 TpIgM 检测有助于神经梅毒的诊断 ,无症状神经梅毒的脑 脊液 TpIgM 检测也可以呈阳性结果。 [ 关键词] 　神经梅毒 ; IgM 抗体 ;梅毒螺旋体 ;脑脊液 ( ) [ 中图分类号] 　R 759. 1 　　　[文献标识码] 　A 　　　[文章编号] 　1001 - 7089 2002 06 - 0376 - 03 Diagnostic Signif icance of IgM Antibodies to Treponema Pallidum in Cerebrospinal Fluid for Neurosyphilis SHI Xin , YAN G Chen ,SHI Yizheng , et al The Second A ttliated Hospital of S uz hou U niversity , S uz hou 215004 , China Abstract : 　Objective 　To explore the significance of IgM antibodies to Treponema pallidum ( TpIgM) in diagnosing neu rosyphilis. Methods 　Using antibody capture EL ISA technology ,we detected TpIgM in cerebrospinal fluid (CSF) samples of 21 patients with neurosyphilis ,28 patients with syphilis and 28 patients with neurological disorders. 28 cases of syphilis whose TPPA in CSF was negative and 28 cases of neurological disorders whose serum RPR and TPPA was negative were used as two control groups. Results 　While negative results were recorded in the two control groups ,the positive rate of TpIgM in CSF was 71. 4 % in neurosyphilis group. The difference was of high statis